Christian Doppler Laboratory of Molecular Stress Research in Peritoneal Dialysis (MSRPD)

Group Kratochwill

Peritoneal dialysis (PD) is a life-saving renal replacement therapy for more than 200,000 patients worldwide. However, PD causes major morbidity and mortality due to infectious complications and peritoneal membrane failure. From a holistic view, this damage must be regarded as imbalance between PD-related cellular insults and counteracting stress responses. Research at the Medical University of Vienna provided clear evidence for dysfunctional cellular stress responses as a novel pathomechanism in PD. Interventions with cytoprotective PD fluids (PDF) restored peritoneal cellular stress responses, and has been developed to first-use-in-man.

The “Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis (CDL-MSRPD)” aims to identify molecular stress signatures as surrogate markers of clinical outcome in PD, and to characterize effects and molecular mechanisms of mode of action of PD-protec™, a novel cytoprotective PDF with added alanyl-glutamine, developed to counteract dysfunctional cellular stress responses in PD.

Priv.-Doz. Dipl.-Ing. Dr. Klaus Kratochwill
Head of CD-Lab

News

 
   

Peritoneal dialysis fluid can be a non-invasive liquid biopsy specimen, but high-abundance proteins mask rarer disease biomarkers.

 
 

Best Submitted PD Abstract at the Annual Dialysis Conference

 
 

(Vienna, 09-10-2017) – CDL-MSRPD researchers Klaus Kratochwill and Rebecca Herzog were presenting their findings to an international audience at the 13th European Peritoneal Dialysis Meeting, which took place on October 4-7, 2017 in Dublin, Ireland...

 
   
 

(Wien, 04-10-2017) – Im Rahmen der gemeinsamen Jahrestagung der Österreichischen Gesellschaften für Nephrologie (ÖGN) und Hypertensiologie (ÖGH), die vom 28.-30. September 2017 in Villach stattgefunden hat, wurde der Vortrag von Dr. Rebecca Herzog..

 
 

(Vienna, 26-09-2017) – This year‘s annual meeting of the ÖGKJ (Österreichische Gesellschaft für Kinder-und Jugendheilkunde (Austrian Society for Pediatric and Adolescent Medicine)) took place in Graz from September 20 to 23. Rebecca Herzog presented..

 
 

PhD student Katarzyna Bialas presented results of her dissertation project at the 2017 Forum for Young Scientists

 
 

"Bauchfelldialyse - Wiener Experten entdecken gewebeschonende Substanz"

 
 

Head of the CDL-MSRPD Klaus Kratochwill and Rebecca Herzog attended the 37th Annual Dialysis Conference in Long Beach, California.

 
 

(Wien, 21-02-2017) – Unter der Tagungsleitung von Prof. Christoph Aufricht fand die 48. Jahrestagung der Gesellschaft für Pädiatrische Nephrologie vom 15.–18.02.2017 in Wien statt. Als Mitorganisator hat CD-Laborleiter Dr. Klaus Kratochwill einen..

 
 

Kathrin Stampf successfully passed her Master thesis “Analysis of the O-GlcNAcome of mesothelial cells after exposure to peritoneal dialysis fluid, using O-GlcNAc immunoprecipitation”.

 
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